Multicellular life was caused by the same gene that suppresses cancer, study suggests

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Biologists at the Kansas State University found that a single gene called retinoblastoma is responsible for the evolution of single-celled organisms into multicellular ones, debunking previous hypotheses that it took multiple genes to create multicellular life.

The same gene is also known to be defective in cancer patients and plays a critical role in the evolution into multicellular life. « Not only did we find a critical gene for multicellularity, it turns out to be a tumour suppressor and it is much easier to evolve multicellularity than anticipated. » said Eric Hanschen, a doctoral student at the University of Arizona and co-researcher.

The researchers compared the multi-cellular Gonium pectoral alga and its single-celled relative Chlamydomonas reinhardtii and found that the RB gene is present in both algae despite small structural cycle differences. And when they introduced the RB gene from Gonium into Chlamydomonas, the latter became multicellular.

« Gonium is representative of the first steps toward the evolution of complex multicellular organisms such as plants and animals, » Olson said. « These findings have the potential to help scientists understand the origin of cancer and may contribute to future abilities to treat and detect cancer. »

Source: Science Alert

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